AI Article Synopsis
- mTOR inhibitors are used for various treatments in both adults and children, but their serious side effects in children are not well understood.
- Common issues include oral ulcers, with a notable case of perianal ulcers reported in an infant post-heart transplant, leading to the discontinuation of the drug.
- Proper identification and management of these side effects in pediatric patients is crucial, but it poses ongoing challenges.
Article Abstract
mTOR inhibitors have a wide spectrum of therapeutic applications in adults and children. Little is known, however, about serious adverse effects in children undergoing mTOR inhibitor therapy. Oral ulcers are common and sometimes severe, but no other gastrointestinal involvement has been reported so far. Here we present a case of everolimus-associated perianal ulcers in an eight-month-old infant, 3 months after heart transplantation, which necessitated the drug's discontinuation. In a thorough series of diagnostic tests, we identified no other cause for the progressive perianal ulceration. The recognition and appropriate management of mTOR inhibitors' adverse effects in pediatric patients are essential and remain challenging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/petr.13072 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!