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Acupuncture for uremic pruritus: A systematic review and meta-analysis protocol.
PLoS One
November 2024
Department of Acupuncture, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Background: Uremic pruritus (UP) or chronic kidney disease-associated pruritus (CKD-aP) is one of the most intractable dermatologic symptom in patients with chronic kidney disease. Several randomized controlled trials (RCTs) have been conducted to investigate the antipruritic effects of acupuncture on UP/CKD-aP and suggested a significant therapeutic effect, while the evidence supporting the application of acupuncture is limited.
Objectives: This study will assess the efficacy and safety of acupuncture for patients with UP/CKD-aP.
Homozygous variants in WDR83OS lead to a neurodevelopmental disorder with hypercholanemia.
Am J Hum Genet
November 2024
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Section of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:
Article Synopsis
- - WDR83OS encodes a protein called Asterix, which works with another protein, CCDC47, to help fold large proteins correctly, specifically those with transmembrane domains.
- - Recent findings linked mutations in CCDC47 and WDR83OS to trichohepatoneurodevelopmental syndrome, showing consistent symptoms like neurodevelopmental disorders, facial dysmorphism, and liver dysfunction across multiple families.
- - A zebrafish model lacking Wdr83os function demonstrated its crucial role in the nervous system and lipid absorption, further establishing a connection between WDR83OS mutations and neurological diseases characterized by elevated bile acids.
Scabies: a clinical update.
Med J Aust
November 2024
Centre for International Child Health, University of Melbourne, Melbourne, VIC.
Scabies is the most common neglected tropical disease with cutaneous manifestations, disproportionately affecting socially disadvantaged populations living in overcrowded settings. Scabies infestation is characterised by a generalised intractable pruritus, and is often complicated by secondary bacterial infection, which can lead to a range of complications. Scabies is a clinical diagnosis and requires an adequate degree of suspicion.
View Article and Find Full Text PDFMicrovillous Inclusion Disease: An Exceedingly Rare Condition With a New Treatment.
ACG Case Rep J
October 2024
Division of Gastroenerology and Hepatology, University of Creighton, Omaha, NE.
Article Synopsis
- Syndromes with congenital diarrhea, hearing loss, and intrahepatic cholestasis are rare and often misdiagnosed as PFIC, but recent genetic studies have identified new genes related to these disorders.
- A 20-year-old woman, diagnosed with PFIC type 1 during childhood, experienced a resurgence of symptoms after a long period of being symptom-free, leading to the use of odevixibat for treatment.
- Whole genome sequencing revealed novel mutations indicating microvillous inclusion disease (MVID), and odevixibat showed effectiveness in alleviating cholestatic pruritus associated with this condition.
A Rash and Intractable Pruritus After Hemodialysis Initiation: Challenge.
Am J Dermatopathol
October 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, MA.
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