Testing for substance toxicity for living organisms is an important step in the development and adaptation of new drugs for various purposes. Analysis of the dependences between toxicological parameters of chemical substances for various test objects and physicochemical properties of these agents is a promising trend. Partition coefficient logP (logK) was chosen as the key physicochemical parameter determining the toxicological parameters of the same substance for hydrobionts at different developmental stages. We found a correlation between decimal logarithm of the ratio of LC for fish embryos to LC for adult fish and logP. This dependence was found as a liner combination of equations obtained by drawing a trend line between experimental points and calculation of Pearson's correlation coefficient R.
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http://dx.doi.org/10.1007/s10517-017-3895-7 | DOI Listing |
Fish Shellfish Immunol
January 2025
College of Fisheries, Huazhong Agricultural University, Wuhan 430070, P.R. China; Engineering Research Center of Green development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Wuhan 430070, P.R. China; Hubei Provincial Engineering Laboratory for Pond Aquaculture, Wuhan 430070, P.R. China; Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan 430070, P.R. China. Electronic address:
Microcystin-leucine-arginine (MC-LR) has been shown to induce neuroinflammation and disrupt neurotransmitter system. However, little is known about the mechanism of toxicity. In this study, male adult zebrafish (Danio rerio) were exposed to MC-LR at concentrations of 0, 0.
View Article and Find Full Text PDFGenes Chromosomes Cancer
January 2025
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Purpose: Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma affecting with predilection the acral soft tissues of middle-aged adults. Clinically, MIFS is associated with a high rate of local recurrence but infrequent distant metastases. The diagnosis remains challenging due to their wide histologic spectrum and overlap with reactive, benign, and low-grade malignant lesions.
View Article and Find Full Text PDFFish Physiol Biochem
January 2025
Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Pituitary gland morphogenesis and the ontogeny of the adenohypophyseal (AH) cells of Astyanax lacustris are presented herein. This Characiformes species shows great ecological and commercial importance, and it has been increasingly used as animal model. For this study, A.
View Article and Find Full Text PDFSci Rep
January 2025
Departments of Biological Sciences CW-405 Biological Sciences Building, University of Alberta Edmonton, Edmonton, AB, T6G 2E9, Canada.
Cannabis is one of the most widely used drugs, and yet an understanding of its impact on the human brain and body is inconclusive. Medicinal and recreational use of cannabis has increased in the last decade with a concomitant increase in use by pregnant women. The major psychoactive compound in cannabis, Δ-tetrahydrocannabinol (THC), exists in different isomers, with the (-) trans isomer most common.
View Article and Find Full Text PDFJACC Clin Electrophysiol
January 2025
Montreal Heart Institute, Montreal, Québec, Canada.
Background: Ventricular tachycardia (VT) substrate characteristics before transcatheter pulmonary valve replacement (TPVR) in repaired tetralogy of Fallot (rTOF) are unknown.
Objectives: In this study, the authors sought to evaluate substrates for sustained monomorphic VT before TPVR in rTOF.
Methods: Retrospective (2017 to 2021) and prospective (commencing 2021) rTOF patients with native right ventricular outflow tract referred for electrophysiology study (EPS) before TPVR were included.
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