AI Article Synopsis
- The study aimed to compare the effectiveness of probiotics and aminosalicylates in maintaining remission for patients with ulcerative colitis.
- A total of six randomized controlled trials involving 721 participants were analyzed, finding no significant difference in effectiveness or adverse event rates between the two treatments.
- Both probiotics and aminosalicylates were found to be effective, but the authors suggest that further high-quality trials are needed to confirm these results.
Article Abstract
Objective: To evaluate the maintenance effect of probiotics versus that of aminosalicylates on ulcerative colitis.
Methods: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the Chinese Biomedical Database were searched in English or Chinese. Data extracted were selected with strict criteria.
Results: In six randomized controlled trials (RCTs), a total of 721 participants were enrolled and the maintenance effect of probiotics ( = 364) versus that of aminosalicylates ( = 357) on ulcerative colitis was investigated. No significant difference was observed between probiotics and aminosalicylate groups (relative risk () = 1.08; 95% confidence interval (): 0.91-1.28; = 0.40). Three RCTs compared the incidence of adverse events with probiotics versus those with aminosalicylates. No significant difference was observed in the incidence of adverse events between the two groups ( = 1.20; 95% : 0.92-1.56; = 0.17).
Conclusions: Probiotics and aminosalicylates both showed a maintenance effect on ulcerative colitis. However, more well-designed RCTs are required.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643593 | PMC |
| http://dx.doi.org/10.1016/j.cdtm.2016.07.002 | DOI Listing |
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