Synthetic biology of microbes synthesizing polyhydroxyalkanoates (PHA).

Synth Syst Biotechnol

School of Life Sciences, Tsinghua University, Beijing 100084, China.

Published: December 2016

Microbial polyhydroxyalkanoates (PHA) have been produced as bioplastics for various purposes. Under the support of China National Basic Research 973 Project, we developed synthetic biology methods to diversify the PHA structures into homo-, random, block polymers with improved properties to better meet various application requirements. At the same time, various pathways were assembled to produce various PHA from glucose as a simple carbon source. At the end, bacteria were reconstructed to produce PHA in changing morphology for low cost production under unsterile and continuous conditions. The synthetic biology will advance the PHA into a bio- and material industry.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625728PMC
http://dx.doi.org/10.1016/j.synbio.2016.09.006DOI Listing

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