AI Article Synopsis
- * Many stem cell niches are well-defined, which allows for better evaluation of how diseases start and progress, particularly through genetic studies.
- * There is a growing need to establish stem cell pathology as a distinct discipline to enhance research and applications in regenerative medicine, with the review highlighting specific areas for future exploration.
Article Abstract
Rapid advances in stem cell biology and regenerative medicine have opened new opportunities for better understanding disease pathogenesis and the development of new diagnostic, prognostic, and treatment approaches. Many stem cell niches are well defined anatomically, thereby allowing their routine pathological evaluation during disease initiation and progression. Evaluation of the consequences of genetic manipulations in stem cells and investigation of the roles of stem cells in regenerative medicine and pathogenesis of various diseases such as cancer require significant expertise in pathology for accurate interpretation of novel findings. Therefore, there is an urgent need for developing stem cell pathology as a discipline to facilitate stem cell research and regenerative medicine. This review provides examples of anatomically defined niches suitable for evaluation by diagnostic pathologists, describes neoplastic lesions associated with them, and discusses further directions of stem cell pathology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857951 | PMC |
| http://dx.doi.org/10.1146/annurev-pathol-020117-043935 | DOI Listing |
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