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Patient-derived response estimates from zero-passage organoids of luminal breast cancer.
Breast Cancer Res
December 2024
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Background: Primary luminal breast cancer cells lose their identity rapidly in standard tissue culture, which is problematic for testing hormone interventions and molecular pathways specific to the luminal subtype. Breast cancer organoids are thought to retain tumor characteristics better, but long-term viability of luminal-subtype cases is a persistent challenge. Our goal was to adapt short-term organoids of luminal breast cancer for parallel testing of genetic and pharmacologic perturbations.
View Article and Find Full Text PDFCOVID-19 infection and later risk of sickness absence by socioeconomic status: a cohort study.
BMC Public Health
December 2024
Finnish Institute of Occupational Health, TYÖTERVEYSLAITOS, PL 18, Helsinki, 00032, Finland.
Background: The COVID-19 pandemic was a significant health risk and resulted in increased sickness absence during the pandemic. This study examines whether a history of COVID-19 infection is associated with a higher risk of subsequent sickness absence.
Methods: In this prospective cohort study, 32,124 public sector employees responded to a survey on COVID-19 infection and lifestyle factors in 2020 and were linked to sickness absence records before (2019) and after (2021-2022) the survey.
Risk Factors and Treatment Strategies for Anastomotic Ulcers in Pediatric Intestinal Failure.
J Pediatr Surg
December 2024
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
Purpose: Anastomotic ulcers (AUs) are a rare cause of morbidity in intestinal failure (IF). Prior studies of AUs have been small, descriptive reports. We evaluated a large cohort of IF patients to identify risk factors and describe treatment strategies for AUs.
View Article and Find Full Text PDFThe effect of digital parental awareness and somatic symptoms on problematic media use in children with attention-deficit/hyperactivity disorder.
J Pediatr Nurs
December 2024
Dicle University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Diyarbakır, Turkey. Electronic address:
Background: Children diagnosed with Attention-deficit/hyperactivity disorder (ADHD) have greater difficulty in regulating their own media usage and are inclined to spend more time engaging in video games compared to neurotypical children. This study aimed to investigate the effects of ADHD severity, digital parenting awareness, and accompanying psychiatric symptoms on children's problematic media (PMU) use in children with ADHD.
Methods: The study included 95 ADHD patients aged between 6 and 11 years and 90 age-and gender-matched healthy controls.
Promoting psychological adaptability and well-being of patients with personality disorders with creative arts and psychomotor therapies: protocol of an intervention mapping study.
BMJ Open
December 2024
Research Group Arts and Psychomotor Therapies in Health Care, HAN University of Applied Sciences, Nijmegen, Gelderland, Netherlands.
Introduction: Personality disorders (PDs) cause much suffering. In treating patients with PDs, it is important not only to focus on reducing symptoms, but also on promoting psychological adaptability and well-being. The experiential nature of Creative Arts and Psychomotor Therapies (CAPTs) contributes to working on psychological adaptability and improving well-being, although more evidence is needed.
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