Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
New Delhi metallo-beta-lactamase (NDM)-mediated carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii is a major concern. We investigated the presence of NDM and its variants in P. aeruginosa and A. baumannii at a tertiary hospital in North India. A total of 236 isolates (130 P. aeruginosa and 106 A. baumannii) were included; 38 (29.23%) P. aeruginosa and 20 A. baumannii isolates (18.8%) were resistant to carbapenems and all of them were bla positive. All 38 carbapenem-resistant P. aeruginosa harbored bla while 12 (60%) of 20 A. baumannii harbored bla. Pulsed-field gel electrophoresis showed that all 58 isolates were clonally unrelated. By Southern blot analysis, bla was located on chromosome. The bla-positive isolates were more frequently recovered from tracheal aspirate (67% vs.16%; p = 0.02) and intensive care unit (67% vs. 20%; p = 0.001) than bla. Among other carbapenemases, VIM was significantly associated with bla than bla (61% vs. 17%; p = 0.006). Mortality between bla- and bla-infected patients was comparable. When expressed in Escherichia coli, bla transformant conferred one doubling dilution higher MIC value for cefotaxime, piperacillin/tazobactam than bla. The study shows the emergence of blamediated resistance among P. aeruginosa and A. baumannii and rapid evolution of bla in A. baumannii with its chromosomal localization.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1089/mdr.2017.0078 | DOI Listing |
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