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Prevalence and Molecular Characterization of New Delhi Metallo-Beta-Lactamases in Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii from India. | LitMetric

AI Article Synopsis

  • NDM-mediated carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii is a critical issue highlighted in this study from a North Indian hospital, revealing a significant presence of resistance among isolates.
  • Out of 236 bacterial samples, 29.23% of P. aeruginosa and 18.8% of A. baumannii were found to be resistant to carbapenems, with all resistant strains testing positive for the bla gene associated with NDM.
  • The research also found that these bla-positive strains were more commonly found in tracheal aspirates and intensive care units, suggesting a concerning trend in antibiotic resistance and the potential for rapid evolution among these bacteria.

Article Abstract

New Delhi metallo-beta-lactamase (NDM)-mediated carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii is a major concern. We investigated the presence of NDM and its variants in P. aeruginosa and A. baumannii at a tertiary hospital in North India. A total of 236 isolates (130 P. aeruginosa and 106 A. baumannii) were included; 38 (29.23%) P. aeruginosa and 20 A. baumannii isolates (18.8%) were resistant to carbapenems and all of them were bla positive. All 38 carbapenem-resistant P. aeruginosa harbored bla while 12 (60%) of 20 A. baumannii harbored bla. Pulsed-field gel electrophoresis showed that all 58 isolates were clonally unrelated. By Southern blot analysis, bla was located on chromosome. The bla-positive isolates were more frequently recovered from tracheal aspirate (67% vs.16%; p = 0.02) and intensive care unit (67% vs. 20%; p = 0.001) than bla. Among other carbapenemases, VIM was significantly associated with bla than bla (61% vs. 17%; p = 0.006). Mortality between bla- and bla-infected patients was comparable. When expressed in Escherichia coli, bla transformant conferred one doubling dilution higher MIC value for cefotaxime, piperacillin/tazobactam than bla. The study shows the emergence of blamediated resistance among P. aeruginosa and A. baumannii and rapid evolution of bla in A. baumannii with its chromosomal localization.

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http://dx.doi.org/10.1089/mdr.2017.0078DOI Listing

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