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Oral Tributyrin Treatment affects Short-Chain Fatty Acid Transport, Mucosal Health, and Microbiome in a Mouse Model of Inflammatory Diarrhea.
J Nutr Biochem
January 2025
Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address:
Butyrate may decrease intestinal inflammation and diarrhea. This study investigates the impact of oral application of sodium butyrate (NaB) and tributyrin (TB) on colonic butyrate concentration, SCFA transporter expression, colonic absorptive function, barrier properties, inflammation, and microbial composition in the colon of slc26a3 mice, a mouse model for inflammatory diarrhea. In vivo fluid absorption and bicarbonate secretory rates were evaluated in the cecum and mid-colon of slc26a3 and slc26a3 mice before and during luminal perfusion of NaB-containing saline and were significantly stimulated in both slc26a3 and slc26a3 colon by NaB.
View Article and Find Full Text PDFAssessment of geochemistry and irrigation suitability of the River Ganga, Varanasi, India: PCA reduction for water quality index and health risk evaluation.
Environ Sci Pollut Res Int
January 2025
Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, 221005, India.
Surface water chemistry of the River Ganga at Varanasi was analyzed at 10 locations over 3 years (2019-2021) across pre-monsoon, monsoon, and post-monsoon seasons. The study aimed to assess water parameters using principal component analysis (PCA), calculate the water quality index (WQI), determine processes governing water chemistry, evaluate irrigation suitability, and estimate non-carcinogenic health risks. The physical parameters measured included pH (8.
View Article and Find Full Text PDFRenal Tubular Acidosis: Core Curriculum 2025.
Am J Kidney Dis
January 2025
Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Renal tubular acidoses (RTAs) are a subset of non-anion gap metabolic acidoses that result from complex disturbances in renal acid excretion. Net acid excretion is primarily accomplished through the reclamation of sodium bicarbonate and the buffering of secreted protons with ammonia or dibasic phosphate, all of which require a series of highly complex and coordinated processes along the renal tubule. Flaws in any of these components lead to the development of metabolic acidosis and/or a failure to compensate fully for other systemic acidoses.
View Article and Find Full Text PDFLimited reactivity of pyroxene and plagioclase in batch experiments with supercritical CO in the presence of NaCl and NaHCO in the context of CO sequestration via carbonation.
Environ Sci Pollut Res Int
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Council for Geoscience, Private Bag X112, Pretoria, 0001, South Africa.
One-step high-pressure and high-temperature direct aqueous mineral carbonation of tailings derived from mining of Platinum Group Metals in South Africa requires a fundamental understanding of the reactivity of the most dominant mineral phases, i.e. pyroxene and plagioclase (66 wt.
View Article and Find Full Text PDFDual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract.
Pharmaceutics
January 2025
Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia.
Article Synopsis
- The study focused on creating gastroretentive tablets using a mucoadhesive-floating system to enhance the bioavailability of gentiopicroside from gentian root extract, aiming for both systemic and local gastric effects.
- The tablets were formulated by direct compression of sodium bicarbonate and solid lipid microparticles, employing quality by design (QbD) methods to analyze factors affecting their properties and performance.
- Key findings highlighted the importance of trehalose content and homogenization time, which positively influenced tablet stability and release rates, leading to successful dual-mechanism gastroretentive tablets that maintain effectiveness in the digestive system for an extended period.
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