Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction. We hypothesize that the phosphodiesterases in maternal plasma, phosphodiesterase-5 in particular, may be linked to clinical manifestations in preeclampsia syndrome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mehy.2017.08.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Evaluation of Adropin and Autotaxin as Potential Markers of Endothelial Dysfunction in Preeclampsia.
Angiology
September 2024
Department of Biochemisty, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Endothelial dysfunction (ED) plays a prominent role in the pathogenesis of preeclampsia (PE). There is a need for non-invasive methods to assess endothelial function in preeclamptic patients. In the present study, adropin, autotaxin (ATX), and lysophosphatidic acid (LPA) were evaluated as indicators of ED.
View Article and Find Full Text PDFFunction of sildenafil on diseases other than urogenital system: An umbrella review.
Front Pharmacol
February 2023
Department of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
To investigate the function of sildenafil on diseases other than urogenital system, an umbrella review was conducted. Meta-analysis and systematic reviews on this topic were comprehensively evaluated in this umbrella review. Quality of evidence was evaluated through AMSTAR and the Grading of Recommendations, Assessment, Development and Evaluation system to generate a reliable and valid conclusion.
View Article and Find Full Text PDFSildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations.
Int J Environ Res Public Health
September 2022
Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia.
View Article and Find Full Text PDFPentoxifylline as a therapeutic option for pre-eclampsia: a study on its placental effects.
Br J Pharmacol
November 2022
Division of Neonatology, Department of Paediatrics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Background And Purpose: Recently pentoxifylline, a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre-eclampsia. We therefore investigated the placental transfer, vascular effects and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas.
Experimental Approach: The placental transfer and metabolism of pentoxifylline were studied using ex vivo placenta perfusion experiments.
Photoacoustic imaging provides an in vivo assessment of the preeclamptic placenta remodeling and function in response to therapy.
Placenta
August 2022
Department of Biomedical Engineering, Tulane University, 500 Lindy Boggs Center, New Orleans, LA, 70118, USA. Electronic address:
Introduction: There is a lack of effective therapeutic interventions for preeclampsia. A central factor in the etiology of the disease is the development of placental hypoxia due to abnormal vascular remodeling. However, methods to assess the impact of potential therapies on placental growth and remodeling are currently lacking.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!