Occurrence of toluene in Canadian total diet foods and its significance to overall human exposure.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess

a Food Research Division , Bureau of Chemical Safety, Health Canada , Ottawa , Ontario , Canada.

Published: January 2018

Levels of most VOCs in foods are usually low because of their volatility, and human exposure to VOCs is expected to be mainly via inhalation of ambient and indoor air. However, dietary exposures to VOCs can be significant to overall exposures if elevated concentrations of VOCs are present in foods consumed in high amounts and/or on a regular basis, and this was demonstrated in this study with the occurrence data of toluene from the recent 2014 Canadian Total Diet Study (TDS). Concentrations of toluene in the composite samples of most food types from the 2014 TDS are low and similar to the results from the previous 2007 TDS with some exceptions, such as beef steak (670 ng/g (2014 TDS) vs. 14 ng/g (2007 TDS)), poultry, chicken and turkey (307 ng/g (2014 TDS) vs. 8.8 ng/g (2007 TDS)). Toluene concentrations in most of the grain-based and fast food composite samples from the 2014 TDS are considerably higher than those from the 2007 TDS, with the highest level of 4655 ng/g found in the composite sample of crackers from the 2014 TDS (compared to 18 ng/g from 2007 TDS). Dietary exposure estimates for toluene based on the occurrence results from the 2014 TDS show that for most of the age groups, grain-based foods are the primary source, accounting for an average of 77.5% of the overall toluene intake from the diet. The highest dietary exposures to toluene were observed for the adult age groups, with estimated average exposures ranging from 177.4 to 184.5 µg/d. Dietary exposure estimates to toluene are well below oral doses associated with toxicological effects and also below the maximum estimated intake (819 µg/d) from air inhalation for adult group (20 - 70 years) based on the results from CEPA (Canadian Environmental Protection Act) assessment in 1992.

Download full-text PDF

Source
http://dx.doi.org/10.1080/19440049.2017.1395520DOI Listing

Publication Analysis

Top Keywords

2014 tds
24
2007 tds
20
tds
12
ng/g 2007
12
canadian total
8
total diet
8
human exposure
8
vocs foods
8
dietary exposures
8
composite samples
8

Similar Publications

Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure.

Neurology

December 2024

From the Boston University Alzheimer's Disease Research Center and Chronic Traumatic Encephalopathy Center (M.U., E.N., S.D., B.A., N.S., A.S., J.P., J.D.C., D.D., B.D., L.G., B.H., D.K., N.K., R.C.C., V.E.A., R.A.S., T.D.S., Y.T., A.C.M., M.L.A., J.M.), Framingham Heart Study (R.B., A.C.M.), Departments of Pathology and Laboratory Medicine (J.D.C., T.D.S., A.C.M.), Neurology (B.D., B.H., D.K., R.C.C., R.A.S., A.C.M., M.L.A., J.M.), Psychiatry (L.G.), Radiology (L.G.), Ophthalmology (L.G.), and Biomedical Engineering (L.G.), Boston University Chobanian & Avedisian School of Medicine; Departments of Applied Social Sciences (S.W.C., D.R.) and Biomedical Engineering (L.G.), Boston University; Department of Biostatistics (F.T.-Z., Z.B., B.M., J.P., Y.T.), Boston University School of Public Health; Spaulding Rehabilitation Hospital (D.D.), Charlestown; Braintree Rehabilitation Hospital (B.D., D.K.); Department of Rehabilitation and Human Performance (K.D.-O.C.), Brain Injury Research Center, Department of Pathology (J.C.), Department of Artificial Intelligence & Human Health, Nash Family Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, and Neuropathology Brain Bank & Research CoRE, Icahn School of Medicine at Mount Sinai, New York, NY; VA Boston Healthcare System (B.H., N.K., V.E.A., T.D.S., A.C.M.); Department of Neurosurgery (R.C.C.), Emerson Hospital, Concord; and VA Bedford Healthcare System (V.E.A., T.D.S., A.C.M.), MA.

Article Synopsis
  • Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to frequent head injuries, often seen in athletes and military personnel, with a focus on its relationship with aggression and family mental health history.
  • The study analyzed data from deceased male brain donors with CTE, aiming to determine if the presence of CTE affects the relationship between first-degree family history of mental illness (1°FHMI) and aggression, using structured assessments and various demographic controls.
  • Results indicated that 1°FHMI was significantly correlated with aggression scores in individuals with CTE, suggesting that CTE pathology may influence aggression differently than previously understood, while no such association was found in those without CTE.
View Article and Find Full Text PDF

Background: Tumor deposits (TDs) are known to have a poor prognosis independent of lymph node (LN) involvement and are considered equivalent to LN metastases in the latest staging system. In stage III colon cancer (CC), high-risk patients (pT4 or pN2) receive 6 months of adjuvant chemotherapy, while low-risk patients (pT1-3 and N1) are recommended either 3 or 6 months of CAPOX or 6 months of FOLFOX therapy. However, the optimal chemotherapy duration for low-risk patients classified as pN1c remains unknown.

View Article and Find Full Text PDF

Enhancing local-scale groundwater quality predictions using advanced machine learning approaches.

J Environ Manage

November 2024

Department of Water Resources Development and Management, Indian Institute of Technology Roorkee, 247667, India. Electronic address:

Assessing groundwater quality typically involves labor-intensive, time-consuming, and costly laboratory tests, making real-time monitoring impractical, especially at the local level. Groundwater quality projections at the local scale using broad spatial datasets have been inaccurate due to variations in hydrogeology, human activities, industrial operations, groundwater extraction, and waste disposal. This study aims to identify the most dependable and resilient machine learning algorithms for forecasting groundwater quality at nearby monitoring locations by utilizing simple water quality metrics that can be quickly assessed without extensive sampling and laboratory testing.

View Article and Find Full Text PDF

The present study focused on the distribution of uranium in groundwater samples collected from various sources in the Chikkaballapur district and its associated risk in humans. Seventy-five groundwater samples were collected during pre-monsoon and post-monsoon seasons and were analysed for uranium concentration along with different water quality parameters. The uranium concentration ranged from 0.

View Article and Find Full Text PDF

Background: The mechanism underlying the formation of gastric tumor deposits (TDs) is unclear. We aimed to explore the risk factors for the formation and prognostic value of TDs.

Methods: This retrospective analysis included 781 locally advanced gastric cancer (LAGC) patients from four medical institutions in China, from June 2014 to June 2018.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!