Impact of reduced tigecycline susceptibility on clinical outcomes of Acinetobacter bacteremia.

J Microbiol Immunol Infect

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Published: February 2018

The higher 14-day mortality rate for patients with Acinetobacter bacteremia receiving tigecycline appropriately compared to other appropriate antibiotics (36.4% versus 14.2%, P = 0.028) was due to the poor effect of tigecycline for isolates with a minimum inhibitory concentration of 2 μg/mL (63.6% of 11 versus 14.2% of 127, P = 0.001).

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http://dx.doi.org/10.1016/j.jmii.2017.08.024DOI Listing

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