AI Article Synopsis
- MicroRNAs (miRNAs) are small RNA molecules that play a key role in regulating gene expression after the DNA is transcribed and are essential for normal development and balance within the body.
- Dysregulated levels of miRNAs can lead to various health issues, including cancer, where they can either promote or inhibit tumor growth depending on the type of cells and their specific target genes.
- One particular miRNA, miR-708-5p, has shown significant involvement in cancer development across different types of tumors, prompting further investigation into its complex role and implications in oncogenesis.
Article Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression post-transcriptionally. They are crucial for normal development and maintaining homeostasis. Researchers have discovered that dysregulated miRNA expression contributes to many pathological conditions, including cancer. miRNAs can augment or suppress tumorigenesis based on their expression and transcribed targetome in various cell types. In recent years, researchers have begun to identify miRNAs commonly dysregulated in cancer. One recently identified miRNA, miR-708-5p, has been shown to have profound roles in promoting or suppressing oncogenesis in a myriad of solid and hematological tumors. This review highlights the diverse, sometimes controversial findings reported for miR-708-5p in cancer, and the importance of further exploring this exciting miRNA.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642637 | PMC |
| http://dx.doi.org/10.18632/oncotarget.19772 | DOI Listing |
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