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The Etiology of Neuronal Development in Craniosynostosis: A Working Hypothesis. | LitMetric

AI Article Synopsis

  • Craniosynostosis is a common condition treated by specialists, leading to both physical deformities and potential cognitive issues in children as they grow up.
  • Surgery is typically performed in infancy to correct skull shape, but there is ongoing debate about the best surgical methods and their effectiveness on cognitive outcomes.
  • Recent advancements in imaging techniques are helping to uncover the causes of brain dysfunction in craniosynostosis patients, which could improve surgical approaches and treatment strategies to mitigate cognitive deficits.

Article Abstract

Craniosynostosis is one of the most common craniofacial conditions treated by neurologic and plastic surgeons. In addition to disfigurement, children with craniosynostosis experience significant cognitive dysfunction later in life. Surgery is performed in infancy to correct skull deformity; however, the field is at a crossroads regarding the best approach for correction. Since the cause of brain dysfunction in these patients has remained uncertain, the role and type of surgery might have in attenuating the later-observed cognitive deficits through impact on the brain has been unclear. Recently, however, advances in imaging such as event-related potentials, diffusion tensor imaging, and functional MRI, in conjunction with more robust clinical studies, are providing important insight into the potential etiologies of brain dysfunction in syndromic and nonsyndromic craniosynostosis patients. This review aims to outline the cause(s) of such brain dysfunction including the role extrinsic vault constriction might have on brain development and the current evidence for an intrinsic modular developmental error in brain development. Illuminating the cause of brain dysfunction will identify the role of surgery can play in improving observed functional deficits and thus direct optimal primary and adjuvant treatment.

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Source
http://dx.doi.org/10.1097/SCS.0000000000004040DOI Listing

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