By using Co(acac)/Xantphos with AlMe, the C(sp)-H bonds of allylarene derivatives were cleaved for reaction with various ketones, affording the homoallylic alcohols in moderate to good yields. The branch/linear selectivity depended on the steric and electronic factors of the ketone electrophiles. The intermediate in this reaction is thought to be a low-valent allylcobalt(I) species, which exhibits high nucleophilicity toward ketones.
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| http://dx.doi.org/10.1021/acs.orglett.7b02871 | DOI Listing |
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