A new triterpene saponin, catomentosaponin (1) and 11 known analogues (2-12) were isolated from the roots of Catunaregam tomentosa. The structures of 1-12 were determined on the basis of extensive NMR and MS data analysis. The sugar residues were identified by co-TLC and HPLC analysis after hydrolysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compound 2 showed moderate cytotoxicity against KB cell with IC value of 24.84 μM.
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