Studies of both humans and non-human primates have demonstrated that aging is typically characterized by a decline in cognition that can occur as early as the fifth decade of life. Age-related changes in working memory are particularly evident and mediated, in part, by the prefrontal cortex, an area known to evidence age-related changes in myelin that is attributed to inflammation. In recent years, several nutraceuticals, including curcumin, by virtue of their anti-inflammatory and antioxidant effects, have received considerable attention as potential treatments for age-related cognitive decline and inflammation. Accordingly, we assessed for the first time in a non-human primate model of normal aging the efficacy of dietary intervention using the natural phenol curcumin to ameliorate the effects of aging on spatial working and recognition memory. Results revealed that monkeys receiving daily administration of curcumin over 14-18 months demonstrated a greater improvement in performance on repeated administration of a task of spatial working memory compared to monkeys that received a control substance.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745216 | PMC |
| http://dx.doi.org/10.1007/s11357-017-9998-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI.
Eur Radiol Exp
January 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Cerebral microbleeds (CMBs) are small, hypointense hemosiderin deposits in the brain measuring 2-10 mm in diameter. As one of the important biomarkers of small vessel disease, they have been associated with various neurodegenerative and cerebrovascular diseases. Hence, automated detection, and subsequent extraction of clinically useful metrics (e.
View Article and Find Full Text PDFExperimental arrangement to study the impact of atmospheric turbulence on user-defined beams.
Rev Sci Instrum
January 2025
Applied and Adaptive Optics Laboratory, Department of Physics, Indian Institute of Space Science and Technology, Thiruvananthapuram 695547, Kerala, India.
In the present work, we propose an experimental setup to investigate the effect of atmospheric turbulence on user-defined beams. The user-defined beams were formed by writing reconfigurable patterns on a spatial light modulator, allowing the impact of atmospheric turbulence to be investigated simultaneously and in real time. The programmable controllability provides several flexibilities to the system, such as the ability to create different beam types simultaneously, control the separation between different beams, compensate for aberrations, and easily switch between different beam types.
View Article and Find Full Text PDFVerbal Encoding Strategies in Visuo-Spatial Working Memory.
J Cogn
January 2025
Department of Psychology, Humboldt-Universität zu Berlin, Berlin, DE.
Visual working memory and verbal storage are often investigated independently of one another. However, a growing body of evidence suggests that naming visual stimuli can provide an advantage in performance during visual working memory tasks. On the other hand, there is also evidence that labeling could lead to biases in recall.
View Article and Find Full Text PDFOptical Imaging of Trigeminal Ganglion Excitation Evoked by Electrical Stimulation of the Trigeminal Nerve.
Cureus
December 2024
Division of Dental Anesthesiology, Faculty of Dentistry Graduate School of Medicine and Dental Sciences, Niigata University, Niigata, JPN.
Background There are many reports of anatomical and physiological studies on trigeminal ganglion neurons, but few studies have analyzed temporal changes in the excitation of the trigeminal ganglion. This study aimed to establish an experimental system for spatial and temporal imaging analysis of the excitatory dynamics of trigeminal ganglion cells evoked by stimulation of a peripheral branch of the trigeminal nerve. Methods After excision of the trigeminal ganglion with the inferior alveolar nerve (IAN) from Sprague Dawley rats (seven to nine weeks old), 400-µm-thick slices of the trigeminal ganglion with the IAN were prepared.
View Article and Find Full Text PDFEvaluating the impact of a hand-crafted 3D-Printed head Model and virtual reality in skull base surgery training.
Brain Spine
December 2024
Department of Neurosurgery, University Hospital of Lausanne and University of Lausanne, 1011, Lausanne, Switzerland.
Introduction: While cadaveric dissections remain the cornerstone of education in skull base surgery, they are associated with high costs, difficulty acquiring specimens, and a lack of pathology in anatomical samples. This study evaluated the impact of a hand-crafted three-dimensional (3D)-printed head model and virtual reality (VR) in enhancing skull base surgery training.
Research Question: How effective are 3D-printed models and VR in enhancing training in skull base surgery?
Materials And Methods: A two-day skull base training course was conducted with 12 neurosurgical trainees and 11 faculty members.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!