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High stability of gold nanoparticles towards DNA modification and efficient hybridization via a surfactant-free peptide route. | LitMetric
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High stability of gold nanoparticles towards DNA modification and efficient hybridization via a surfactant-free peptide route.

Xin-Yi Li Fu-Yan Feng Zi-Tong Wu Yi-Zhen Liu Xiao-Dong Zhou Ji-Ming Hu

Chem Commun (Camb)

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Published: October 2017

With the assistance of peptides, a stable and highly efficient approach for the quick loading of thiol-DNA onto AuNPs is proposed with a high DNA utilization, which is generally applicable to specific DNA detection and diverse AuNP sizes. The maximum efficiency of hybridization reached 93% while the reaction time was shortened to 30 min.

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 Source
http://dx.doi.org/10.1039/c7cc06827aDOI Listing

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