Cyanamide is a prebiotically plausible compound that has previously been invoked as a phosphate activating agent. However, its reactions with phosphate monoesters are very slow and tend to be low yielding. We now report a fast and efficient phosphate activation reaction using cyanamide in the presence of glyoxylate or pyruvate. These simple 2-oxoacid salts are shown to function as catalysts and in an optimised system, adenosine-3'-phosphate was converted to adenosine-2',3'-cyclic phosphate in 95% yield.
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| http://dx.doi.org/10.1039/c7cc07517k | DOI Listing |
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