We propose a novel scheme to generate ultra-bright ultra-short γ-ray flashes and high-energy-density attosecond positron bunches by using multi-dimensional particle-in-cell simulations with quantum electrodynamics effects incorporated. By irradiating a 10 PW laser pulse with an intensity of 10 W/cm onto a micro-wire target, surface electrons are dragged-out of the micro-wire and are effectively accelerated to several GeV energies by the laser ponderomotive force, forming relativistic attosecond electron bunches. When these electrons interact with the probe pulse from the other side, ultra-short γ-ray flashes are emitted with an ultra-high peak brightness of 1.8 × 10 photons smmmrad per 0.1%BW at 24 MeV. These photons propagate with a low divergence and collide with the probe pulse, triggering the Breit-Wheeler process. Dense attosecond ee pair bunches are produced with the positron energy density as high as 10 J/m and number of 10. Such ultra-bright ultra-short γ-ray flashes and secondary positron beams may have potential applications in fundamental physics, high-energy-density physics, applied science and laboratory astrophysics.
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http://dx.doi.org/10.1364/OE.25.021583 | DOI Listing |
Purpose: To develop a rapid, high-resolution and distortion-free quantitative $R_{2}^{*}$ mapping technique for fetal brain at 3 T.
Methods: A 2D multi-echo radial FLASH sequence with blip gradients is adapted for fetal brain data acquisition during maternal free breathing at 3 T. A calibrationless model-based reconstruction with sparsity constraints is developed to jointly estimate water, fat, $R_{2}^{*}$ and $B_{0}$ field maps directly from the acquired k-space data.
BMC Public Health
January 2025
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Background: Compared to older adults with breast cancer (BC), adolescents and young adults (AYAs) develop more aggressive disease necessitating more intensive therapy with curative intent, which is disruptive to planned life trajectories. The burden of unmet needs among AYA BC survivors exists in two domains: (1) symptoms (e.g.
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January 2025
Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research (IGSNRR), Chinese Academy of Sciences (CAS), Beijing, 100101, China.
Flash flood susceptibility mapping is essential for identifying areas prone to flooding events and aiding decision-makers in formulating effective prevention measures. This study aims to evaluate the flash flood susceptibility in the Yarlung Tsangpo River Basin (YTRB) using multiple machine learning (ML) models facilitated by the H2O automated ML platform. The best-performing model was used to generate a flash flood susceptibility map, and its interpretability was analyzed using the Shapley Additive Explanations (SHAP) tree interpretation method.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Mathematical Sciences, Faculty of Science, Somali National University, Mogadishu Campus, Mogadishu, Somalia.
In recent years, machine learning has gained substantial attention for its ability to predict complex chemical and biological properties, including those of pharmaceutical compounds. This study proposes a machine learning-based quantitative structure-property relationship (QSPR) model for predicting the physicochemical properties of anti-arrhythmia drugs using topological descriptors. Anti-arrhythmic drug development is challenging due to the complex relationship between chemical structure and drug efficacy.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
FLASH radiotherapy (FLASH RT) is an innovative modality in cancer treatment that delivers ultrahigh dose rates (UHDRs), distinguishing it from conventional radiotherapy (CRT). FLASH RT has demonstrated the potential to enhance the therapeutic window by reducing radiation-induced damage to normal tissues while maintaining tumor control, a phenomenon termed the FLASH effect. Despite promising outcomes, the precise mechanisms underlying the FLASH effect remain elusive and are a focal point of current research.
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