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An exceptionally rare case of a giant parathyroid adenoma with carcinoma-like presentation.
Hormones (Athens)
January 2025
Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Giant parathyroid adenoma (GPA) is an extremely rare cause of primary hyperparathyroidism (PHPT) and may sometimes mimic parathyroid carcinoma (PC). Parathyroid carcinoma is also a very rare entity. Both preoperative and postoperative diagnosis of the two conditions remains a challenge.
View Article and Find Full Text PDFEvaluation of Sepsis Severity Using Combined High-Density Lipoprotein and Red Cell Distribution Width Indicators.
Br J Hosp Med (Lond)
December 2024
Department of General Medicine, The Second People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, China.
Sepsis is a life-threatening condition resulting from dysregulated immune responses to infection, leading to organ dysfunction. High-density lipoprotein (HDL) and red cell distribution width (RDW) have shown significant correlations with sepsis severity, yet the combined prognostic value of HDL and RDW in evaluating sepsis severity and outcomes remains unclear. This study examines the relationship between HDL and RDW levels and sepsis severity, as well as evaluates the combined utility of these markers in predicting disease severity and patient outcomes.
View Article and Find Full Text PDFRetrospective evaluation of dexamethasone for treatment of suspected critical illness-related corticosteroid insufficiency in dogs with septic shock (2017-2022): 60 cases.
J Vet Emerg Crit Care (San Antonio)
January 2025
Critical Care, Blue Pearl, Tampa, Florida, USA.
Objective: To retrospectively compare and report vasopressor duration and mortality of septic dogs with hypotension refractory to vasopressor administration (presumed critical illness-related corticosteroid insufficiency [CIRCI]) treated with or without dexamethasone sodium phosphate (DxSP).
Design: Retrospective study (2017-2022).
Setting: Tertiary referral and teaching hospitals.
MitoStores: stress-induced aggregation of mitochondrial proteins.
Biol Chem
January 2025
Cell Biology, 26562 RPTU University of Kaiserslautern, Erwin-Schrödinger-Strasse 13, D-67663 Kaiserslautern, Germany.
Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into mitochondria. If the rate of protein synthesis exceeds the capacity of the mitochondrial import machinery, precursor proteins can transiently accumulate in the cytosol. The cytosolic accumulation of mitochondrial precursors jeopardizes cellular protein homeostasis (proteostasis) and can be the cause of diseases.
View Article and Find Full Text PDFCan biodegradable plastics mitigate plastamination? Feedbacks from marine organisms.
J Hazard Mater
January 2025
Stazione Zoologica Anton Dohrn, Department of Ecosustainable Marine Biotechnology, Via Ammiraglio Ferdinando Acton 55, Naples 80133, Italy; Department of Biology University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Vicinale Cupa Cintia 26, Naples 80126, Italy; Institute of Water Research (IRSA) CNR Taranto, Italy. Electronic address:
The EU plastic strategy aims to reduce the environmental impact of the increasing plastic production, by replacing petrochemical-based polymers with biodegradable ones. But this mitigation measure for the plastamination might, in turn, generate bio-based microplastics in environments that are not necessarily safe. Biodegradable and non-biodegradable plastics, polylactic acid (PLA) and polypropylene (PP) respectively, and their leachates were used for testing microplastic (MP) effects on seven marine species from different trophic levels, including bacteria, algae, rotifers, copepods, amphipods and branchiopods.
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