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Feasibility of a Pharmabuddy Care Service for patients with Parkinson's disease.
BMC Health Serv Res
December 2024
SIR Institute for Pharmacy Practice and Policy, Leiden, the Netherlands.
Background: Pharmaceutical care for patients with Parkinson's disease (PD) is complex. Specialized pharmaceutical care provided by a dedicated pharmacy team member (pharmabuddy) for these patients may reduce medication-related problems. The feasibility of this service for PD patients is unknown.
View Article and Find Full Text PDF"The End of the Golden Weather": therapeutic strategies for mantle cell lymphoma relapsed or refractory to covalent BTK inhibitors.
Haematologica
November 2024
Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; Linear Clinical Research, Nedlands, WA, Australia; Medical School, University of Western Australia, Nedlands, WA.
Article Synopsis
- Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma that frequently relapses after initial treatment, leading to an ongoing need for improved management strategies.
- Patients often respond to covalent Bruton's tyrosine kinase inhibitors (cBTKi) during the first relapse, but these responses are not long-lasting, highlighting the need to understand why some patients develop resistance.
- The review suggests focusing on advanced treatment options, such as CAR T-cell therapy and other innovative therapies like non-covalent BTK inhibitors and antibody-drug conjugates, while encouraging participation in clinical trials.
Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds.
Cell Death Dis
October 2024
Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Langerhans cells (LCs) are resident dendritic cells in the epidermis and their roles in presenting antigens derived from microorganisms present in the skin has been well appreciated. However, it is generally thought that incoming neutrophils are mainly responsible for eradicating invading pathogens in the early stage of wounds and a role of LCs in innate immunity is elusive. In the current study, we showed that wounds absent of LCs had a delayed closure.
View Article and Find Full Text PDFSystemic Factors Contributing to Gender Differences in Living Kidney Donation: A Systematic Review and Meta-Synthesis Using the Social-Ecological Model Lens.
Am J Nephrol
October 2024
Research Institute of the McGill University Health Centre, Montreal, Québec, Canada.
Article Synopsis
- - The study investigates why women, particularly mothers and wives, tend to be more prevalent as living kidney donors, highlighting the need to consider relational, community, and socio-cultural factors in decision-making rather than just individual motivations.
- - A systematic review of 16 studies from 13 countries revealed minimal differences in individual motives between male and female donors, but significant variations were found in relational, community, and socio-cultural influences, such as family dynamics and societal norms.
- - The findings indicate that gender disparities in living kidney donation stem from complex interconnections among various factors, suggesting the necessity of addressing systemic contributors to gender inequities to promote more balanced donation practices.
Cancer Nurses' Voices and Recommendations to Address Workforce Challenges: A Qualitative Analysis.
Semin Oncol Nurs
October 2024
Monash Nursing and Midwifery, Monash University, Victoria, Australia.
Objectives: Amidst the fulfilment of making a positive impact on patients' lives, cancer nurses also contend with high workloads, limited resources, and barriers to career advancement. Understanding the perceptions of cancer nurses is essential in addressing these challenges and fostering an environment that promotes both professional satisfaction and optimal patient care. Our aim was to explore Australian cancer nurses' experiences and perspectives of workforce challenges and their proposed solutions to address them.
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