AI Article Synopsis
- The text discusses the need for a sensitive technique to monitor the distribution of metallic nanoparticles in cancer therapy.
- Inductively coupled plasma mass spectrometry (ICP-MS) is highlighted as an effective tool for tracking these metal components.
- A standardized method for processing biological samples and preparing controls is presented, initially using gold nanoparticles, but adaptable for other metals as well.
Article Abstract
The increasing exploration of metallic nanoparticles for use as cancer therapeutic agents necessitates a sensitive technique to track the clearance and distribution of the material once introduced into a living system. Inductively coupled plasma mass spectrometry (ICP-MS) provides a sensitive and selective tool for tracking the distribution of metal components from these nanotherapeutics. This chapter presents a standardized method for processing biological matrices, ensuring complete homogenization of tissues, and outlines the preparation of appropriate standards and controls. The method described herein utilized gold nanoparticle-treated samples; however, the method can easily be applied to the analysis of other metals.
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| http://dx.doi.org/10.1007/978-1-4939-7352-1_4 | DOI Listing |
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