Palladium-catalyzed methylene β-C(sp)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp)-H bond activation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640319 | PMC |
| http://dx.doi.org/10.1021/acscatal.7b02905 | DOI Listing |
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