-positive isolates phenotypically susceptible to cefoxitin (-methicillin-sensitive [MSSA]) have been identified. We describe the treatment and outcomes among patients with -MSSA bloodstream infections (BSI) and MRSA BSI matched 1:1 for age, BSI origin, and BSI type ( = 17 per group). Compared to MRSA BSI patients, -MSSA BSI patients more often experienced clinical failure (58.8% and 11.8%, = 0.010), driven largely by persistent bacteremia (35.3% and 11.8%). -MSSA BSI patients may be at higher risk for poor clinical outcomes.
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http://dx.doi.org/10.1128/AAC.01396-17 | DOI Listing |
Pathogens
November 2024
Laboratorio de Investigación en Microbiología y Resistencia Antimicrobiana, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
The poor prognosis of infections associated with multidrug-resistant can be attributed to several conditions of the patient and virulence factors of the pathogen, such as the type III secretion system (T3SS), which presents the ability to inject four effectors into the host cell: ExoS, ExoT, ExoU and ExoY. The aim of this study was to analyze the distribution of genes through multiplex polymerase chain reaction in strains isolated from patients at a third-level pediatric hospital and their relationships with clinical variables, e.g.
View Article and Find Full Text PDFJ Clin Med
December 2024
Center for Clinical Epidemiology, Odense University Hospital, Kløvervænget 30, Entrance 216, Ground Floor, DK-5000 Odense C, Denmark.
Little is known about the clinical characteristics and pathogens causing hospital-acquired bloodstream infections (HA-BSIs) in relation to an intensive care unit (ICU) stay. Population-based cohort study, comprising 35% of the Danish population, 2009-2016. We derived four patient groups with first-time HA-BSIs: no ICU stay during the admission (non-ICU patients) and HA-BSI acquired before, in, or after an ICU stay (before-ICU, in-ICU, and after-ICU patients).
View Article and Find Full Text PDFJ Med Microbiol
January 2025
Division of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, UK.
Bloodstream infections (BSIs) are one of the most serious infections investigated by microbiologists. However, the time to detect a BSI fails to meet the rapidity required to inform clinical decisions in real time. Blood culture (BC) is considered the gold standard for diagnosing bloodstream infections.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Department of Infectious Diseases, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Background: Droplet digital PCR (ddPCR) is a highly sensitive tool for detecting bacterial DNA in bacterial bloodstream infections (BSI). This study aimed to examine the sensitivity and specificity of ddPCR and the association between bacterial DNA load in whole blood and the time-to-positivity (TTP) of blood culture (BC) in patients with Escherichia coli BSI.
Methods: This prospective study enrolled patients with E.
Lancet Oncol
January 2025
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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