AI Article Synopsis
- A meta-analysis was conducted on 14 studies with a total of 37,941 Alzheimer’s cases and 49,727 controls to evaluate the impact of specific genetic variations in the sortilin-related receptor gene (SORL1) on Alzheimer's disease.
- Findings indicated that two specific single nucleotide polymorphisms (SNPs), rs641120 and rs1010159, were linked to an increased risk of Alzheimer's in Asian populations, while rs689021 was associated with a reduced risk in Caucasians.
- Overall, this research provides strong evidence of a significant relationship between SORL1 polymorphisms and the risk of developing Alzheimer’s disease in different populations.
Article Abstract
A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin related receptor on Alzheimer’s disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations. Given thesedata, crucial evidence is provided to demonstrate that a significantrelationship exists between SORL1 polymorphisms and susceptibility to Alzheimer’s disease.
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| http://dx.doi.org/10.31083/JIN-170051 | DOI Listing |
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