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Linkage studies in a large fragile X family. | LitMetric

Linkage studies in a large fragile X family.

Am J Hum Genet

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, England.

Published: November 1988

We have analyzed the segregation of five loci in the region Xq27/28 in a large family affected by the fragile X syndrome. The marker DXS115 (767) is shown to be polymorphic with the enzyme PstI, as well as with BstXI. This marker will be useful in the analysis of both fragile X and haemophilia A families. The data presented here are consistent with the following order of loci: Xcen-F9-DXS105(cX55.7,55E)-DXS98(4D-8)- FRAXA-DXS52(St14)-DXS115(767)-qter.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715522PMC

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