AI Article Synopsis
- Understanding the molecular mechanisms of drug adsorption/desorption is crucial for designing effective pharmaceutical formulations using superparamagnetic iron oxide nanoparticles (SPIONs) in biomedical applications.
- Research on the cytostatic drug Mitoxantrone (MTO) revealed that its adsorption to lauric acid-albumin hybrid coated SPIONs (SEON) enhances stability and sustainable drug release compared to uncoated nanoparticles and protein solutions.
- Techniques like FTIR, DLS, and neutron/X-ray scattering were employed to study MTO interactions with SEON, indicating that MTO molecules are located on the outer surface of the nanoparticle coating, affecting their repulsive interactions.
Article Abstract
A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEON) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering. Such MTO-loaded nanoparticles have shown very promising results in in vivo animal models before, while the exact binding mechanism of the drug was unknown. SEON formulations have shown better stability under drug loading in comparison with uncoated nanoparticle and sustainable drug release to compare with protein solution. Adsorption of MTO to SEON leads to decreasing of absolute value of zeta potential and repulsive interaction among particles, which points to the location of separate molecules of MTO on the outer surface of LA-HSA shell.
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| http://dx.doi.org/10.1016/j.colsurfb.2017.09.057 | DOI Listing |
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