With microwave irradiation, the submonomer synthesis of dipeptoids on functionalized cellulose can be accelerated with good yields and purity. Optimization provided a library of 96 dipeptoids. From these, 29 compounds were found with an antibacterial activity against MRSA at a concentration of 25 μM. Large nonpolar residues, such as undecylamine and dehydroabiethylamine, are the key components engendering the observed antibacterial activity of these peptoids.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931720 | PMC |
| http://dx.doi.org/10.1021/acscombsci.7b00096 | DOI Listing |
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