This paper studies the robust stabilization problem for a class of uncertain nonlinear systems with unstable zero dynamics. The considered zero dynamic is not assumed to be input-to-state practically stable and contains nonlinear uncertainties and mismatched external disturbances. A new robust adaptive fuzzy control method is developed by combining theory with backstepping technique. First, an ideal virtual control function is designed, which can guarantee the zero dynamic asymptotically stable with a suboptimal performance. Then, based on some non-negative functions and backstepping design, the actual controller is constructed for the overall system, which ensures that the tracking error for the ideal virtual control signal converges to a priori accuracy regardless of external disturbances. In this design, an auxiliary signal is introduced to overcome the difficulties from the unavailable virtual reference signal. By exploiting the implicit function theorem, the proposed design technique is directly applied to a special case, where the zero dynamic is partially linear. A two inverted pendulums is used to illustrate the application and effectiveness of the proposed design method.
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http://dx.doi.org/10.1109/TCYB.2017.2758385 | DOI Listing |
JCI Insight
January 2025
Division of Nephrology, Department of Medicine, Vanderbildt University Medical Center, Nashville, United States of America.
Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine, and increasing the risk of progressive kidney disease. However, the regenerative capacity of the renal medulla after reversal of obstruction is poorly understood. To investigate this, we developed a mouse model of reversible urinary obstruction.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
Artificial Intelligence Lab, School of Computer and Information Sciences, University of Hyderabad, Hyderabad, 500046, India.
The generalization of deep learning (DL) models is critical for accurate lesion segmentation in breast ultrasound (BUS) images. Traditional DL models often struggle to generalize well due to the high frequency and scale variations inherent in BUS images. Moreover, conventional loss functions used in these models frequently result in imbalanced optimization, either prioritizing region overlap or boundary accuracy, which leads to suboptimal segmentation performance.
View Article and Find Full Text PDFArch Microbiol
January 2025
Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden.
Bacteria experience a continual array of environmental stresses, necessitating adaptive mechanisms crucial for their survival. Thermophilic bacteria, such as Thermus thermophilus, face constant environmental challenges, particularly high temperatures, which requires robust adaptive mechanisms for survival. Studying these extremophiles provides valuable insights into the intricate molecular and physiological processes used by extremophiles to adapt and survive in harsh environments.
View Article and Find Full Text PDFmSphere
January 2025
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Existing genetic classification systems for porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2), such as restriction fragment length polymorphisms and sub-lineages, are unreliable indicators of close genetic relatedness or lack sufficient resolution for epidemiological monitoring routinely conducted by veterinarians. Here, we outline a fine-scale classification system for PRRSV-2 genetic variants in the United States. Based on >25,000 U.
View Article and Find Full Text PDFBiotechnol Prog
January 2025
Automation, Digital and Learning Solutions, Cytiva, Karlsruhe, Germany.
Mechanistic modeling of chromatographic steps is an effective tool in biopharma process development that enhances process understanding and accelerates optimization efforts and subsequent risk assessment. A relatively new model for ion exchange chromatography is the colloidal particle adsorption (CPA) formalism, which promises improved separation of material and molecule-specific parameters. This case study demonstrates a straightforward CPA modeling workflow to describe an ion exchange chromatography polishing step of a knobs-into-holes construct bispecific antibody molecule.
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