Objective: Asthma is a multifaceted inflammatory disorder which results into narrowing of airway with broncho-constriction and spasm. As the complex pathophysilogy of asthma, various animal models are generally used to investigate the immunological and physiological pathogenesis of disease. Linn (Fabacease) is a climbing shrub. The leaves and roots are sweet in taste and traditionally used for the treatment of asthma, bronchititis, and inflammation. possesses different pharmacological activities. Hence the objective of this study was to evaluate antiasthmatic activity of ethanol extract of leaves using various models.
Methods: In present study ethanol extract of leaves was evaluated for antiasthmatic activity using carrageenan induced paw edema in rats [100-150 mg/kg], histamine induced bronchospasm in guinea pig [200-400 mg/kg] and histamine induced contraction of goat tracheal chain [2.5-25 μg/ml].
Results: Result of study revealed that ethanol extract of significantly exhibited anti-inflammatory effects in rats, oral treatment of extract on guinea pig significantly increases histamine induced preconvulsive dysponea times and the ethanol extract of plant increases got tracheal chain precontracted with histamine.
Conclusion: Hence present study concludes that ethanol extract of possesses antiasthmatic activity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634729 | PMC |
| http://dx.doi.org/10.1016/j.jtcme.2016.12.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Louisville, Lousiville, KY, USA.
Background: Chronic, excessive alcohol consumption causes neurodegeneration and is associated with an increased risk for Alzheimer's disease (AD) and other dementias. Moreover, there has been a consistent rise in alcohol consumption in older adults in the past few decades. However, there is minimal research showing how alcohol consumption affects AD neuropathogenesis and biological mechanisms remain unclear.
View Article and Find Full Text PDFFirst Report of Causing Root Rot of Incense Cedar in Tennessee and the United States.
Plant Dis
January 2025
Tennessee State University, Otis Floyd Nursery Research Center, 472 Cadillac Lane, McMinnville, Tennessee, United States, 37110;
Incense cedar [ (Torr.) Florin] is a coniferous evergreen tree, indigenous to western North America, that is being evaluated in Tennessee for its adaptability to eastern U.S.
View Article and Find Full Text PDFTherapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria.
Sci Rep
January 2025
Departmment of Microbiology and Immunology, Kampala International University, Ishaka, Uganda.
Antimicrobial resistance poses a global public health threat, compelling the search for alternative treatments, especially in resource-limited settings. The increasing ineffectiveness of traditional antibiotics has intensified the need to explore medicinal plants as viable therapeutic options. This study sought to compare the efficacy of certain medicinal plants used in Owerri, Nigeria, for treating pathogenic bacteria against traditional commercial antibiotics.
View Article and Find Full Text PDFEffect of isolated compounds from Combretum trifoliatum on toxicity and detoxification enzymes in Nilaparvata lugens.
Sci Rep
January 2025
Animal Toxicology and Physiology Speciality Research Unit, Zoology Department, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
The brown planthopper (BPH) Nilaparvata lugens (Stål) is a major insect pest of Oryza sativa that causes crop yield loss in tropical regions, including Thailand. In this study, the crude ethanolic extract of the leaves and branches of Combretum trifoliatum , its active isolated components, apigenin and camphor, and Finopril were tested for their ability to control the first to fifth instars of N. lugens.
View Article and Find Full Text PDFEthanolic extract of Akhuni induces ROS-mediated apoptosis through ERK and AKT signalling pathways: Insights from metabolic profiling and molecular docking studies.
Free Radic Biol Med
December 2024
Centre for Pre-clinical Studies, CSIR-North East Institute of Science and Technology (NEIST), Jorhat, Assam, 785006, India; AcSIR-Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, 201002, India. Electronic address:
Akhuni, an ethnic food of northeast India, induces ROS-mediated apoptosis in cancer cells. This is the first report on the anticancer potential of Akhuni. Akhuni is a traditional fermented soybean product known for its umami taste and delicacy, commonly used in Northeast India's cuisine.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!