We have developed a highly regioselective homogeneous gold(I)-catalyzed -hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au-Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634393 | PMC |
| http://dx.doi.org/10.1021/acscatal.7b02567 | DOI Listing |
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