AI Article Synopsis
- - Nickel (Ni) is commonly found in various industries like alloys, welding, and electronics, but exposure can lead to serious health issues such as tumors and nervous system damage.
- - Recent studies show that Ni-induced nerve damage is linked to problems with mitochondria, the energy-producing parts of cells.
- - This paper aims to explore the neurotoxicity caused by Ni, uncover the mechanisms behind it, and identify potential drugs that could help prevent nerve damage.
Article Abstract
Nickel (Ni) is widely used in many industrial sectors such as alloy, welding, printing inks, electrical and electronics industries. Excessive environmental or occupational exposure to Ni may result in tumor, contact dermatitis, as well as damages to the nervous system. In recent years, more and more research has demonstrated that Ni induced nerve damages are related to mitochondrial dysfunction. In this paper, we try to characterize Ni induced neurotoxicity as well as the underlying mechanisms, and how to find new drugs for chemoprevention, by reviewing chemicals with neuroprotective effects on Ni induced neurotoxicity.
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| http://dx.doi.org/10.1016/j.tox.2017.10.006 | DOI Listing |
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