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Advances and counterpoints in type 2 diabetes. What is ready for translation into real-world practice, ahead of the guidelines.
BMC Med
September 2024
Social Alchemy: Building Physician Competency Across the Globe, 5 Ave Sur #36, Antigua, Sacatepéquez, Guatemala.
This review seeks to address major gaps and delays between our rapidly evolving body of knowledge on type 2 diabetes and its translation into real-world practice. Through updated and improved best practices informed by recent evidence and described herein, we stand to better attain A1c targets, help preserve beta cell integrity and moderate glycemic variability, minimize treatment-emergent hypoglycemia, circumvent prescribing to "treatment failure," and prevent long-term complications. The first topic addressed in this review concerns updates in the 2023 and 2024 diabetes treatment guidelines for which further elaboration can help facilitate integration into routine care.
View Article and Find Full Text PDFWhich Modality of SFRT Should be Considered First for Bulky Tumor Radiation Therapy, GRID or LATTICE?
Semin Radiat Oncol
July 2024
Department of Radiation Oncology, University of Southern California, Los Angeles, CA.
Spatially fractionated radiation therapy (SFRT), also known as the GRID and LATTICE radiotherapy (GRT, LRT), the concept of treating tumors by delivering a spatially modulated dose with highly non-uniform dose distributions, is a treatment modality of growing interest in radiation oncology, physics, and radiation biology. Clinical experience in SFRT has suggested that GRID and LATTICE therapy can achieve a high response and low toxicity in the treatment of refractory and bulky tumors. Limited initially to GRID therapy using block collimators, advanced, and versatile multi-leaf collimators, volumetric modulated arc technologies and particle therapy have since increased the capabilities and individualization of SFRT and expanded the clinical investigation of SFRT to various dosing regimens, multiple malignancies, tumor types and sites.
View Article and Find Full Text PDFI can't handle my desires: Development and validation of a self-report measure of desire intolerance and associations with distress intolerance.
Psychol Assess
December 2023
Department of Psychological Science, University of Arkansas.
Desire intolerance is conceptualized as a motivational counterpoint to the transdiagnostic risk factor of distress intolerance and is defined as the inability or unwillingness to "sit with" the motivation to approach a rewarding object or task. The current work describes the development and validation of a novel measure of desire intolerance. After initial item development and exploratory factor analysis (Study 1) and confirmatory factor analysis (Study 2), the 10-item unidimensional Desire Intolerance Questionnaire (DIQ) was created.
View Article and Find Full Text PDFHome working at a public university due to the COVID-19 pandemic: challenges and opportunities.
Rev Bras Med Trab
March 2022
Departamento de Saúde do Trabalhador, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Introduction: The COVID-19 pandemic made it necessary to rapidly adapt ways of working, forcing adoption of home working, and public higher education institutions were no exception to this trend.
Objectives: To analyze the initial phase of implementation of emergency teleworking at a public university, including its ramifications and repercussions for workers.
Methods: This article constitutes a narrative account of the university's experience with teleworking, evaluated by analysis of a report produced by the institution after a survey of the needs of workers assigned to emergency teleworking because of the health crisis.
Clinical Controversies in Psoriatic Disease: The Use of IL-17i/IL-23i Versus TNFi as First-line Advanced Therapy in Psoriatic Arthritis.
J Rheumatol
June 2022
Y.Y. Leung, MB, ChB, MD, Department of Rheumatology, Singapore General Hospital, and Duke-NUS Medical School, Singapore.
Psoriatic arthritis (PsA) is a complex, heterogeneous disease, with disease activity in various domains. In recent years, many novel treatments with diverse mechanisms of action have been introduced into the clinical setting. Numerous factors go into the choice and sequencing of different therapies for individual patients.
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