Objective: It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls.
Methods: This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion.
Results: Sodium excretion was greater for patients with early RA (2,849±1,350 vs. 2,182±751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028).
Conclusion: Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640209 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186157 | PLOS |
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