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Identifying Demographic and Clinical Determinants of Ischemic Workup in Patients with Heart Failure.
J Clin Med
November 2024
Department of Cardiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.
Coronary artery disease (CAD) is a common and treatable cause of heart failure (HF), but ischemic evaluation is often overlooked when evaluating patients with new-onset HF. Here, we sought to discern demographic and clinical predictors of ischemic workup in patients with newly diagnosed HF. A retrospective study of 200 consecutive patients with new-onset HF admitted to our safety-net hospital between 2011 and 2015 was performed.
View Article and Find Full Text PDFRevisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti-Citrullinated Peptide/Protein Antibodies.
ACR Open Rheumatol
January 2025
Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Objective: Autoantibodies serve as essential clinical biomarkers and may indicate etiological mechanisms in rheumatic diseases. In light of the increasing knowledge concerning the diversity and biologic implications of anti-citrullinated peptide/protein antibodies (ACPAs), we have re-evaluated the association between the ACPA response and the HLA-DRB1 allelic groups, known to represent a major genetic risk factor for rheumatoid arthritis (RA).
Methods: We explored a collection of 4,392 well-characterized incident patients with RA of White European descent from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) new-onset RA study, as well as 1,199 cases of patients with RA of Southeast Asian origin from the Malaysian EIRA study.
Dyschloremia and Renal Outcomes in Critically Ill Patients With Sepsis: A Prospective Cohort Study: Dyschloremia and Renal Outcomes in Sepsis.
Crit Care Res Pract
October 2024
Department of Nephrology Kasturba Medical College Manipal Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Article Synopsis
- Chloride levels, often overlooked in critically ill patients, can indicate serious outcomes, such as acute kidney injury (AKI) and major adverse kidney events (MAKE30) in those with sepsis.
- In a study involving 400 sepsis patients, hypochloremia was found to be a significant risk factor for adverse kidney outcomes, with 32.3% of patients showing low chloride levels within 72 hours of ICU admission.
- Conversely, hyperchloremia did not demonstrate any significant association with MAKE30 or worsening AKI, suggesting that low chloride levels are more critical to monitor in sepsis patients.
Background/aims: Crohn's Disease (CD) can affect the entire gastrointestinal tract, including the upper sections (UGI), which is often overlooked, especially in Asian populations. There's a notable gap in research regarding the impact of UGI involvement on the intricate landscape of ensuing complications. This study aims to address this gap.
View Article and Find Full Text PDFBeyond survival: understanding post-intensive care syndrome.
Acute Crit Care
May 2024
Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
Post-intensive care syndrome (PICS) refers to persistent or new onset physical, mental, and neurocognitive complications that can occur following a stay in the intensive care unit. PICS encompasses muscle weakness; neuropathy; cognitive deficits including memory, executive, and attention impairments; post-traumatic stress disorder; and other mood disorders. PICS can last long after hospital admission and can cause significant physical, emotional, and financial stress for patients and their families.
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