AI Article Synopsis
- A Mendelian randomization study was conducted on a large cohort of Southern Chinese women (n = 12,233) to explore the link between age at menarche and depressive symptoms.
- The researchers created a genetic allele score through stepwise regression and cross-validation methods.
- The study found no significant association between older age at menarche and higher scores on the geriatric depression scale, indicating that other factors may be responsible for increased depression rates in women.
Article Abstract
To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.
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| http://dx.doi.org/10.1016/j.psychres.2017.09.040 | DOI Listing |
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