Food cultures have developed in communities as according to the produce of local farms in the vicinity. The industrial revolution resulted in large cities and towns becoming reliant on farm produce from the neighbouring countryside; this stimulated development of farming, which itself became industrialized. However, although local diets in Europe differed markedly, the 'healthiness' of all diets was unquestioned until recently. Early in the 20th century, academic departments studying nutrition were established, but it is only since the 1980s that much interest in the 'healthiness' of our food began to be of concern outwith academia. At about this time it was becoming clear that existing patterns of farming and food production were having negative effects on the environment. Since the 1990s, environmental, farming and nutritional sciences have each progressed, but in parallel, and there has been all too little effort to unite them. However, it is clear that, in general, production of foods associated with 'unhealthy' nutrition is also the most damaging from an environmental viewpoint.This article summarizes the evidence on current European diets, analyses costs and benefits in transitioning to healthy and sustainable diets, identifies sustainable dietary guidelines as the way forward and discusses the role of public health in achieving dietary reform in the interests of improved nutrition and environmental protection.
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http://dx.doi.org/10.1093/eurpub/ckx162 | DOI Listing |
Cell Stem Cell
December 2024
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Institute of Neurosciences, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain; CIBERNED, 08036 Barcelona, Spain; Creatio, Production and Validation Center of Advanced Therapies, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain. Electronic address:
iScience
April 2024
Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.
Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that impact several diseases. We hypothesized that we could gain new insights into PADI2 function through a systematic evolutionary and structural analysis.
View Article and Find Full Text PDFNat Commun
February 2024
Barcelona Supercomputing Center (BSC), Plaça Eusebi Güell, 1-3, 08034, Barcelona, Spain.
Exploring the molecular basis of disease severity in rare disease scenarios is a challenging task provided the limitations on data availability. Causative genes have been described for Congenital Myasthenic Syndromes (CMS), a group of diverse minority neuromuscular junction (NMJ) disorders; yet a molecular explanation for the phenotypic severity differences remains unclear. Here, we present a workflow to explore the functional relationships between CMS causal genes and altered genes from each patient, based on multilayer network community detection analysis of complementary biomedical information provided by relevant data sources, namely protein-protein interactions, pathways and metabolomics.
View Article and Find Full Text PDFEur J Hum Genet
February 2024
Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Nat Metab
November 2023
Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B and molecular hallmarks of methionine starvation. Supplementation with vitamin B increases the efficiency of reprogramming both in mice and in cultured cells, the latter indicating a cell-intrinsic effect.
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