Sufficient training examples are the fundamental requirement for most of the learning tasks. However, collecting well-labelled training examples is costly. Inspired by Zero-shot Learning (ZSL) that can make use of visual attributes or natural language semantics as an intermediate level clue to associate low-level features with high-level classes, in a novel extension of this idea, we aim to synthesise training data for novel classes using only semantic attributes. Despite the simplicity of this idea, there are several challenges. First, how to prevent the synthesised data from over-fitting to training classes? Second, how to guarantee the synthesised data is discriminative for ZSL tasks? Third, we observe that only a few dimensions of the learnt features gain high variances whereas most of the remaining dimensions are not informative. Thus, the question is how to make the concentrated information diffuse to most of the dimensions of synthesised data. To address the above issues, we propose a novel embedding algorithm named Unseen Visual Data Synthesis (UVDS) that projects semantic features to the high-dimensional visual feature space. Two main techniques are introduced in our proposed algorithm. (1) We introduce a latent embedding space which aims to reconcile the structural difference between the visual and semantic spaces, meanwhile preserve the local structure. (2) We propose a novel Diffusion Regularisation (DR) that explicitly forces the variances to diffuse over most dimensions of the synthesised data. By an orthogonal rotation (more precisely, an orthogonal transformation), DR can remove the redundant correlated attributes and further alleviate the over-fitting problem. On four benchmark datasets, we demonstrate the benefit of using synthesised unseen data for zero-shot learning. Extensive experimental results suggest that our proposed approach significantly outperforms the state-of-the-art methods.
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http://dx.doi.org/10.1109/TPAMI.2017.2762295 | DOI Listing |
J Exp Biol
January 2025
Department of Biology, Colorado State University, Fort Collins, CO, USA.
Decapod crustaceans regulate molting through steroid molting hormones, ecdysteroids, synthesized by the molting gland (Y-organ, YO). Molt-inhibiting hormone (MIH), a neuropeptide synthesized and secreted by the eyestalk ganglia, negatively regulates YO ecdysteroidogenesis. MIH signaling is mediated by cyclic nucleotide second messengers.
View Article and Find Full Text PDFExplor Res Clin Soc Pharm
March 2025
College of Pharmacy, Qatar University, PO Box 2713, Doha, Qatar.
Background: Asthma self-management is an effective approach that empowers patients with asthma to control their condition and reduce its impact on their daily lives.
Objective: This systematic review aims to synthesize evidence regarding the knowledge, perceptions, facilitators, and barriers related to asthma self-management among patients.
Methods: A systematic literature search was conducted across five databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar) using specific key terms.
RSC Med Chem
January 2025
Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University Mansoura 35516 Egypt
Novel thiazole analogs 3a, 3b, 4, 5, 6a-g, 8a, 8b, 9a-c, 10a-d and 11 were designed and synthesized as molecular mimetics of sunitinib. antitumor activity of the obtained compounds was investigated against HepG2, HCT-116, MCF-7, HeP-2 and HeLa cancer cell lines. The obtained data showed that compounds 3b and 10c are the most potent members toward HepG2, HCT-116, MCF-7 and HeLa cells.
View Article and Find Full Text PDFBr J Pain
January 2025
Centre for Pain Research, School of Health, Leeds Beckett University, Leeds, UK.
Introduction: Social prescribing links patients to community groups and services to meet health needs; however, it is uncertain what the benefits and impacts of social prescribing are for people with chronic pain. The National Institute for Health and Care Excellence (NICE) undertook a systematic review to investigate the clinical and cost effectiveness of social interventions aimed at improving the quality of life of people with chronic pain; no relevant clinical studies comparing social interventions with standard care for chronic pain were found, though the inclusion criteria for studies was narrow.
Objectives: To undertake a rapid review of all types of research and policy on social prescribing for adults with chronic pain in the U.
Cancer Control
January 2025
Department of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Medical School of Nantong University, Nantong, PR China.
Background: Macrophages are a critical component of the innate immune system, derived from monocytes, with significant roles in anti-inflammatory and anti-tumour activities. In the tumour microenvironment, however, macrophages are often reprogrammed into tumour-associated macrophages (TAMs), which promote tumour growth, metastasis, and therapeutic resistance.
Purpose: To review recent advancements in the understanding of macrophage polarisation and reprogramming, highlighting their role in tumour progression and potential as therapeutic targets.
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