AI Article Synopsis
- The study examined the use of hot packs to alleviate pain (hyperalgesia) in rats that were physically inactive due to having both hind limbs immobilized for four weeks.
- Four groups of male Wistar rats were tested: a control group, a physically inactive group (PI), a PI group with a sham treatment, and a PI group receiving hot pack therapy.
- Results showed that while PI and PI + sham groups experienced increased pain and nerve growth factor (NGF) levels, the group treated with hot packs experienced significantly reduced pain and NGF levels, indicating the effectiveness of hot pack therapy in this context.
Article Abstract
We focused on the analgesic effect of hot packs for mechanical hyperalgesia in physically inactive rats. Male Wistar rats were randomly divided into four groups: control, physical inactivity (PI), PI + sham treatment (PI + sham), and PI + hot pack treatment (PI + hot pack) groups. Physical inactivity rats wore casts on both hind limbs in full plantar flexed position for 4 weeks. Hot pack treatment was performed for 20 min a day, 5 days a week. Although mechanical hyperalgesia and the up-regulation of NGF in the plantar skin and gastrocnemius muscle were observed in the PI and the PI + sham groups, these changes were significantly suppressed in the PI + hot pack group. The present results clearly demonstrated that hot pack treatment was effective in reducing physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF in plantar skin and gastrocnemius muscle.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10717048 | PMC |
| http://dx.doi.org/10.1007/s12576-017-0574-4 | DOI Listing |
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