[The role of autologous hemopoietic stem cell transplantation in T-cell lymphoma. Hungarian data].

Orv Hetil

II. Belgyógyászati Klinika és Kardiológiai Központ, Hematológiai Osztály, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.

Published: October 2017

T-cell lymphoma is a poor prognostic hematological malignancy. The generally used - not sufficiently effective - induction chemotherapy should be improved with consolidative autologous hemopoetic stem cell transplantation. The authors describe the role, place and effectiveness of transplantation in this disorder. One hundred thirty three autologous stem cell transplantations were performed in the last 22 years in Hungary. Detailed results are available from the last 6 years. In this period 43 transplantations were carried out in 4 Hungarian centers. Carmustine-etoposide-cytosine arabinoside-melphalan (BEAM) conditioning regimen was used in 95%. The transplantation was done mainly in complete remission (84%), 1 year after transplantation 65% of patients were still in complete remission. Eleven patients died, 82% of them have progressive disease. Brentuximab vedotin has already proved the effectiveness, several other chemoterapeutics, monoclonal antibodies, kinase inhibitors are under investigation. In certain cases allogeneic stem cell transplantation has real indication among therapeutic options. Orv Hetil. 2017; 158(41): 1615-1619.

Download full-text PDF

Source
http://dx.doi.org/10.1556/650.2017.30869DOI Listing

Publication Analysis

Top Keywords

stem cell
16
cell transplantation
12
t-cell lymphoma
8
complete remission
8
transplantation
6
[the role
4
role autologous
4
autologous hemopoietic
4
stem
4
hemopoietic stem
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!