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Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation.
BMC Vet Res
November 2024
Centro de Investigação Interdisciplinar Em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, Lisbon, 1300-477, Portugal.
Background: Studying the effect of dietary Spirulina and lysozyme supplementation on the metabolome and proteome of liver tissue contributes to understanding potential hepatic adaptations of piglets to these novel diets. This study aimed to understand the influence of including 10% Spirulina on the metabolome and proteome of piglet liver tissue. Three groups of 10 post-weaned piglets, housed in pairs, were fed for 28 days with one of three experimental diets: a cereal and soybean meal-based diet (Control), a base diet with 10% Spirulina (SP), and an SP diet supplemented with 0.
View Article and Find Full Text PDFDistinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants.
J Clin Invest
December 2024
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) represent starkly diverging clinical phenotypes, yet may be caused by mutations to the same sarcomeric protein. The precise mechanisms by which point mutations within the same gene bring about phenotypic diversity remain unclear. Our objective was to develop a mechanistic explanation of diverging phenotypes in two TPM1 mutations, E62Q (HCM) and E54K (DCM).
View Article and Find Full Text PDFPotential Mechanisms of Tunneling Nanotube Formation and Their Role in Pathology Spread in Alzheimer's Disease and Other Proteinopathies.
Int J Mol Sci
October 2024
Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Article Synopsis
- Alzheimer's disease (AD) is the most common dementia, and its exact causes are still unclear, with major hypotheses focusing on cholinergic, beta-amyloid, and Tau proteins, while newer research looks into immunological factors and proteins like alpha-synuclein and TDP-43.
- Recent studies highlight tunneling nanotubes (TNTs) as crucial for the spread of harmful proteins in the brains of AD patients; these structures can link non-adjacent cells and may transport proteins like Aβ and Tau between them.
- Current treatments for AD mainly address symptoms and have shown limited success with Aβ-targeting drugs, making the study of TNTs essential for understanding the disease better and finding new therapies.
Levels of Natural Antibodies Before and After Immunoglobulin Replacement Treatment Affect the Clinical Phenotype in Common Variable Immunodeficiency.
J Clin Immunol
September 2024
Laboratory of Immunology, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.
Article Synopsis
- Natural antibodies (NAbs) are essential for immune defense and regulation, playing a role in preventing autoimmunity and maintaining immune balance, particularly relevant in conditions like Common Variable Immunodeficiency (CVID).
- This study analyzed NAb levels in 56 CVID patients and healthy controls, revealing that IgM NAb levels were significantly lower in IgRT-treated patients compared to untreated patients and controls, with treatment not fully restoring these levels.
- The findings suggest a link between low NAb levels and recurrent infections, while patients with enteropathy or autoimmune diseases showed higher IgM NAb levels, indicating that NAb levels may help monitor disease progression in CVID.
Titanium vs PEO Surface-Modified Magnesium Plate Fixation in a Mandible Bone Healing Model in Sheep.
ACS Biomater Sci Eng
August 2024
Department of Oral and Maxillofacial Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of the Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1, Berlin 13353, Germany.
Titanium plates are the current gold standard for fracture fixation of the mandible. Magnesium alloys such as WE43 are suitable biodegradable alternatives due to their high biocompatibility and elasticity modulus close to those of cortical bone. By surface modification, the reagibility of magnesium and thus hydrogen gas accumulation per time are further reduced, bringing plate fixation with magnesium closer to clinical application.
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