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Persistent urticarial eruption preceding systemic features of adult-onset Still's disease: A case report.
Australas J Dermatol
December 2024
Department of Dermatology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
Adult-onset Still's disease (AOSD) is a rare autoinflammatory systemic disorder classically characterised by inflammatory polyarthritis, daily fevers and a transient asymptomatic salmon-pink maculopapular rash that typically arises with the onset of fevers. We report a case of AOSD presenting with a severely pruritic urticarial eruption starting 6 weeks prior to the onset of fever and arthritis and complicated by macrophage activation syndrome. This case highlights the importance of early recognition of diverse cutaneous manifestations of AOSD to facilitate timely diagnosis and treatment to improve disease outcomes.
View Article and Find Full Text PDFACKR1ECs Promote Aortic Dissection Through Adjusting Macrophage Behavior.
Circ Res
December 2024
Department of Cardiovascular Surgery, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Guangdong, China. (Y.W., X.J., Y. Zhang, X.Z., Q.Z.).
Background: Type A aortic dissection (TAAD) is a life-threatening condition characterized by complex pathophysiology, in which macrophages play a critical but not yet fully understood role. This study focused on the role of endothelial cells with elevated expression of ACKR1 (atypical chemokine receptor 1) and their interaction with proinflammatory macrophages in TAAD development.
Methods And Results: Single-cell transcriptomic analysis of human aortic tissues revealed increased populations of endothelial cells exhibiting high ACKR1 expression and proinflammatory macrophages in TAAD samples.
Features of hyperinflammation link the biology of EBV infection and cytokine storm syndromes.
J Allergy Clin Immunol
November 2024
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Overt immune activation by viral infections can lead to cytokine storm syndromes, such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS).
Objective: We aim to compare the immune response to different viral pathogens to understand the connection between infections and cytokine storm syndromes.
Methods: We recruited children who presented to the emergency room with fever for ≥ 3 days.
Extracellular peroxiredoxin 5 exacerbates atherosclerosis via the TLR4/MyD88 pathway.
Atherosclerosis
January 2025
Heart-Immune-Brain Network Research Center, Department of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea; Imvastech Inc., 52 Ewhayeodae-gil, Seodaemun-gu, Seoul, 03760, Republic of Korea. Electronic address:
Backgroungd And Aims: Peroxiredoxin 5 (PRDX5), an atypical 2-Cys peroxiredoxin (PRDX), is known to regulate global oxidative stresses and inflammatory responses. Inflammation and oxidative stress are pivotal factors in the development of atherosclerosis, especially in the context of vascular endothelial dysfunction. However, effects of PRDX5 on atherosclerosis remain unclear.
View Article and Find Full Text PDFFunctional characterization of peroxiredoxin 5 from yellowtail clownfish (Amphiprion clarkii): Immunological expression assessment, antioxidant activities, heavy metal detoxification, and nitrosative stress mitigation.
Dev Comp Immunol
November 2024
Department of Marine Life Sciences & Center for Genomic Selection in Korean Aquaculture, Jeju National University, Jeju, 63243, South Korea; Marine Life Research Institute, Jeju National University, Jeju, 63333, South Korea. Electronic address:
Peroxiredoxin 5 (Prdx5) is the last recognized member of Prdx family. It is a unique, atypical, 2-Cys antioxidant enzyme, protecting cells from death caused by reactive oxygen species (ROS). In this study, the Prdx5 ortholog of Amphiprion clarkii (AcPrdx5) was identified and characterized to explore its specific structural features and functional properties.
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