AI Article Synopsis
- * Superconducting quantum interference device magnetometry shows that these nanoparticles contain isolated Gd ions even at high metal loadings, which contributes to their efficacy.
- * The study emphasizes the importance of hydration, fast water exchange rates, and minimal antiferromagnetic interactions in achieving high relaxivity, leading to better MRI contrast agents.
Article Abstract
This study reports the preparation of a series of gadolinium-polydopamine nanoparticles (GdPD-NPs) with tunable metal loadings. GdPD-NPs are analyzed by nuclear magnetic relaxation dispersion and with a 7-tesla (T) magnetic resonance imaging (MRI) scanner. A relaxivity of 75 and 10.3 mM s at 1.4 and 7 T is observed, respectively. Furthermore, superconducting quantum interference device magnetometry is used to study intraparticle magnetic interactions and determine the GdPD-NPs consist of isolated metal ions even at maximum metal loadings. From these data, it is concluded that the observed high relaxivities arise from a high hydration state of the Gd(III) at the particle surface, fast rate of water exchange, and negligible antiferromagnetic coupling between Gd(III) centers throughout the particles. This study highlights design parameters and a robust synthetic approach that aid in the development of this scaffold for T -weighted, high relaxivity MRI contrast agents.
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| http://dx.doi.org/10.1002/smll.201701830 | DOI Listing |
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