AI Article Synopsis
- - Cellular senescence in primary human CD8 T cells leads to a unique senescence-associated secretory phenotype (SASP), which includes specific chemokines, cytokines, and proteases, contributing to age-related inflammation.
- - The CD8 CD45RA CD27 EMRA subset of T cells exhibits significant heterogeneity, with some cells similar to naïve T cells and others resembling effector memory cells, but they all share a distinct secretory profile indicating senescence.
- - The SASP in senescent CD8 T cells is regulated by p38 MAPK signaling, highlighting the complex processes involved in the senescence of this T cell subset.
Article Abstract
Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8 T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contribute to age-associated inflammation. We found the CD8 CD45RA CD27 EMRA subset to be the most heterogeneous, with a population aligning with the naïve T cells and another with a closer association to the effector memory subset. However, despite the differing processes that give rise to these senescent CD8 T cells once generated, they both adopt a unique secretory profile with no commonality to any other subset, aligning more closely with senescence than quiescence. Furthermore, we also show that the SASP observed in senescent CD8 T cells is governed by p38 MAPK signalling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770853 | PMC |
| http://dx.doi.org/10.1111/acel.12675 | DOI Listing |
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