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| http://dx.doi.org/10.1113/JP274553 | DOI Listing |
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Inhibition of EphA2 by syndecan-4 in wounded skin regulates clustering of fibroblasts.
J Mol Cell Biol
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School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
Upon injury, fibroblasts in the surrounding tissue become activated, migrating into the wound in a controlled manner. Once they arrive, they contract the wound and remodel the stroma. While certain cell surface receptors promote fibroblast migration, others cause repulsion between fibroblasts upon contact, seemingly opposing their clustering within the wound bed.
View Article and Find Full Text PDFDopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus.
J Neurophysiol
December 2024
Department of Biological Sciences, Lehigh University 111 Research Drive, Bethlehem, PA 18015 USA.
The thalamic reticular nucleus (TRN) is a thin shell of gap junction coupled GABAergic inhibitory neurons that regulate afferent sensory relay of the thalamus. The TRN receives dopaminergic innervation from the midbrain, and it is known to express high concentrations of D1 and D4 receptors. Although dopaminergic modulation of presynaptic inputs to TRN has been described, the direct effect of dopamine on TRN neurons and its electrical synapses is largely unknown.
View Article and Find Full Text PDFNrf2 Regulates Inflammation by Modulating Dendritic Cell-T Cell Crosstalk during Viral-Bacterial Superinfection.
J Immunol
December 2024
Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Article Synopsis
- Millions get influenza yearly, often complicated by secondary bacterial pneumonia, with inflammatory cytokines playing a role in susceptibility.
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Metabolic Crosstalk in Multimorbidity: Identifying Compensatory Effects Among Diabetes, Hypertension, and Dyslipidemia.
J Endocr Soc
August 2024
Department of Chemical Science and Technology, University of Rome "Tor Vergata," 00133 Rome, Italy.
Context: Metabolomics is becoming increasingly popular for detecting markers that indicate the presence of a specific disease. However, it is usually applied to studying individual ailments, yielding results that may not be directly relevant to people with multiple health conditions.
Objective: Our study proposes a different approach to explore metabolic crosstalk between various disease states.
Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation.
Cell Commun Signal
September 2024
Department of Biology, Georgia State University, Atlanta, GA, USA.
Post-translational SUMOylation of nuclear and cytosolic proteins maintains homeostasis in eukaryotic cells and orchestrates programmed responses to changes in metabolic demand or extracellular stimuli. In excitable cells, SUMOylation tunes the biophysical properties and trafficking of ion channels. Ion channel SUMOylation status is determined by the opposing enzyme activities of SUMO ligases and deconjugases.
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