We propose a new approach to improving photodynamic therapy (PDT) by transporting zinc phthalocyanine (ZnPc) in biological systems via a graphene nanoflake, to increase its targeting. Indeed, by means of time-dependent density functional theory simulations, we show that the ZnPc molecule in interaction with a graphene nanoflake preserves its optical properties not only in a vacuum but also in water. Moreover, molecular dynamic simulations demonstrate that the graphene nanoflake/ZnPc association, as a carrier, permits one to stabilize the ZnPc/graphene nanoflake system on the cellular membrane, which was not possible when using ZnPc alone. We finally conclude that the graphene nanoflake is a good candidate to transport and stabilize the ZnPc molecule near the cell membrane for a longer time than the isolated ZnPc molecule. In this way, the choice of the graphene nanoflake as a nanovector paves the way to ZnPc PDT improvement.
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http://dx.doi.org/10.1021/acsami.7b09054 | DOI Listing |
Int J Mol Sci
January 2025
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
In this study, we developed a facile one-pot synthesis of a nanocomposite consisting of silver nanoparticles (AgNPs) growing over graphene oxide (GO) nanoflakes (AgNPs@GO). The process consists of the in situ formation of AgNPs in the presence of GO nanosheets via the spontaneous decomposition of silver(I) acetylacetonate (Ag(acac)) after dissolution in water. This protocol is compared to an ex situ approach where AgNPs are added to a waterborne GO nanosheet suspension to account for any attractive interaction between preformed nanomaterials.
View Article and Find Full Text PDFRSC Adv
January 2025
CAS Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences Chengdu 610041 China.
A novel multilayer nanoflake structure of manganese oxide/graphene oxide (γ-MnO/GO) was fabricated a simple template-free chemical precipitation method, and the modified carbon felt (CF) electrode with γ-MnO/GO composite was used as an anode material for microbial fuel cells (MFCs). The characterization results revealed that the γ-MnO/GO composite has a novel multilayer nanoflake structure and offers a large specific surface area for bacterial adhesion. The electrochemical analyses demonstrated that the γ-MnO/GO composite exhibited excellent electrocatalytic activity and enhanced the electrochemical reaction rate and reduced the electron transfer resistance, consequently facilitating extracellular electron transfer (EET) between the anode and bacteria.
View Article and Find Full Text PDFAnal Methods
January 2025
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
Non-invasive continuous detection using tears or sweat as substitutes for blood samples has become an emerging method for real-time monitoring of human health. However, its development is limited by the low sample volume and low level of analytes. The simultaneous determination of multi-analytes with highly sensitive electrochemical sensing platforms has undoubtedly resulted in breakthrough innovations.
View Article and Find Full Text PDFNat Commun
January 2025
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, PL 30-348, Krakow, Poland.
Atomically precise synthesis of graphene nanostructures on semiconductors and insulators has been a formidable challenge. In particular, the metallic substrates needed to catalyze cyclodehydrogenative planarization reactions limit subsequent applications that exploit the electronic and/or magnetic structure of graphene derivatives. Here, we introduce a protocol in which an on-surface reaction is initiated and carried out regardless of the substrate type.
View Article and Find Full Text PDFAnalyst
January 2025
Department of Engineering Design, Indian Institute of Technology Madras, India.
High throughput intracellular delivery of biological macromolecules is crucial for cell engineering, gene expression, therapeutics, diagnostics, and clinical studies; however, most existing techniques are either contact-based or have throughput limitations. Herein, we report a light-activated, contactless, high throughput photoporation method for highly efficient and viable cell transfection of more than a million cells within a minute. We fabricated reduced graphene oxide (rGO) nanoflakes that was mixed with a polydimethylsiloxane (PDMS) nanocomposite thin sheet with an area of 3 cm and a thickness of ∼600 μm.
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