Genomic characterization of an extensively drug-resistant KPC-2-producing Klebsiella pneumoniae ST855 (CC258) only susceptible to ceftazidime-avibactam isolated in Brazil.

Caio Augusto Martins Aires Michael J Rybak Juwon Yim Polyana Silva Pereira Cláudio M Rocha-de-Souza Rodolpho Mattos Albano Valdelucia Oliveira Cavalcanti Ana Paula D'Alincourt Carvalho-Assef Marisa Zenaide Ribeiro Gomes Marise Dutra Asensi

Diagn Microbiol Infect Dis

Laboratório de Pesquisa em Infecção Hospitalar (LAPIH), Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil. Electronic address:

Published: December 2017

This study focuses on a specific isolate of Klebsiella pneumoniae that is extensively drug-resistant (XDR) and produces the KPC-2 enzyme.
Whole-genome sequencing was used to analyze its genetic characteristics and understand its clinical background.
The isolate is part of clonal complex 258 and contains various genes and mutations that contribute to its resistance to multiple antibiotics.

In this study, we describe the genetic features of an XDR KPC-2-producing Klebsiella pneumoniae isolate by using whole-genome sequencing, its clinical-epidemiological context and susceptibility against antimicrobial combinations. The isolate belongs to clonal complex 258 and harbors several acquired genes and mutations associated with antimicrobial resistance.

Download full-text PDF	Source
http://dx.doi.org/10.1016/j.diagmicrobio.2017.08.017	DOI Listing

Publication Analysis

Top Keywords

kpc-2-producing klebsiella

klebsiella pneumoniae

genomic characterization

characterization extensively

extensively drug-resistant

drug-resistant kpc-2-producing

pneumoniae st855

st855 cc258

cc258 susceptible

susceptible ceftazidime-avibactam

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!