Background: Rhinoscleroma is a chronic granuloma that is endemic in Egypt and is caused by gram-negative bacilli (Klebsiella rhinoscleromatis). The nasal mucosa is affected in almost all cases, which causes nasal obstruction, anosmia, and epistaxis. The disease usually passes through an atrophic stage (atrophic rhinitis) and a granulomatous stage before ending in the fibrotic stage, with possible bone destruction.
Objective: This study assessed the effect of topical mitomycin C (MMC) on reducing the recurrence of granulation tissue and intranasal adhesions after endoscopic debulking and continuous medical treatment of nasal rhinoscleroma.
Materials And Methods: This double-blind randomized clinical trial was performed with 30 patients who had rhinoscleroma (granulomatous and fibrotic stages). At the end of endoscopic debulking, meshes impregnated with MMC was placed in one nasal cavity for 5 minutes, while another meshes impregnated with saline solution were placed in the opposite side. Repeated meshes with MMC were placed in the same side during the follow-up period. Patients were followed up for 1 year. The recurrence of granulation tissue and the degree of intranasal adhesions were recorded and compared according to the Lund-Kennedy score.
Results: At 12 months' follow-up, among the total 30 patients, 30 MMC sides were compared with 30 control sides: 69% of MMC sides versus 32% of control sides had no recurrence of granulation tissue (p = 0.01) and 65% of MMC sides versus 24% of control sides had no recurrence of intranasal adhesions (p = 0.03). The Lund-Kennedy score decreased from 2.1 ± 0.64 to 0.8 ± 0.41 and from 2.3 ± 0.33 to 1.9 ± 0.20 in the MMC sides and control sides, respectively, with a nonstatistically significant lower incidence of intranasal adhesions in the MMC sides.
Conclusion: Topical MMC may reduce granulation tissue and intranasal adhesion formation in patients with rhinoscleroma. Further studies with a larger number of samples and longer follow-up periods are recommended.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2500/ajra.2015.29.4197 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disparities in Medication Prescriptions and Post-Tracheostomy Outcomes in Pediatric Patients.
Ann Otol Rhinol Laryngol
January 2025
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Granulation tissue formation and tracheitis are common pediatric tracheostomy complications. Ciprofloxacin/dexamethasone is frequently prescribed, but the influence of social determinants on this topic is unexplored.
Methods: This study extends a prior cohort study of pediatric tracheostomy patients at a single academic institution from 2016 to 2020.
Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis.
Int J Biol Sci
January 2025
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Insulin-like growth factor 2 (IGF2) is a mitogenic peptide hormone expressed by various tissues. Although it is three times more abundant in serum than IGF1, its physiological and pathological roles are yet to be fully understood. Previous transcriptome sequencing studies have shown that IGF2 expression is increased in hypertrophic scar (HS); however, its role in HS formation and the underlying mechanism remains elusive.
View Article and Find Full Text PDFHyperbaric Oxygen Therapy Combined With Standard Wound Care Versus Standard Wound Care Alone in Patients With Diabetic Foot Ulcers: A Prospective Comparative Study.
Cureus
December 2024
General Surgery, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Mumbai, IND.
Background Non-healing diabetic foot ulcers (DFUs) are significant risk factors for amputations. Though the available literature suggests that adjuvant hyperbaric oxygen therapy (HBOT) fastens the healing process and reduces the risk of amputations, its overall evidence in the reduction of amputation remains controversial. Thus, the present study aimed to compare the efficacy and safety of adjuvant HBOT and standard wound care (SWC) with SWC alone in patients with DFUs.
View Article and Find Full Text PDFOxygenous and biofilm-targeted nanosonosensitizer anchored with Pt nanozyme and antimicrobial peptide in the gelatin/sodium alginate hydrogel for infected diabetic wound healing.
Int J Biol Macromol
December 2024
Department of Pharmaceutics, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:
Sonodynamic therapy is an emerging therapeutic approach for combating bacterial infections. However, the characteristics of hypoxia, high HO microenvironment, and the formation of persistent biofilms in diabetic wound sites limit its efficacy in this field. To address these issues, we developed a multifunctional antibacterial hydrogel dressing PPCN@Pt-AMPs/HGel with the cross-linked gelatin and sodium alginate as the matrix, where the nanosonosensitizer PCN-224 was decorated with the oxygen-generating Pt nanoenzyme and further coupled with a biofilm-targeting antimicrobial peptide via an interacting polydopamine layer.
View Article and Find Full Text PDFDesign and characterization of a ROS-responsive antibacterial composite hydrogel for advanced full-thickness wound healing.
Int J Biol Macromol
December 2024
School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. Electronic address:
Full-thickness skin wounds remian a significant and pressing challenge. In this study, we introduce a novel composite hydrogel, CS + GA + Zn-HA. This hydrogel is formulated by incorporating 1 % (1 g/100 mL) of bioactive Zinc-substituted hydroxyapatite nanoparticles (Zn-HA) and 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!