AI Article Synopsis
- Thy-1 is a membrane glycoprotein mainly found in brain tissue and, less frequently, in lymphoid tissue, with its gene located on chromosome 11q22.3.
- In mice, there are two forms of Thy-1, but in humans, researchers have identified two polymorphic alleles (8 and 9) based on an MspI site, occurring at frequencies of 0.7 and 0.3 in a northern European population.
- This discovery of Thy-1 alleles could help in identifying associations with disease genes situated near the same chromosome region (11q22).
Article Abstract
Thy-1 is a membrane glycoprotein expressed predominantly in brain tissue and occasionally in lymphoid tissue. The human Thy-1 gene is located on chromosome 11q22.3. Although two allelic forms of Thy-1 exist in mice (Thy-1.1 and Thy-1.2), no allelic forms have been described for the human Thy-1 gene. We describe a polymorphic MspI site within the human Thy-1 gene that distinguishes two alleles, 8 and 9, which are represented in a northern European population at frequencies of 0.7 and 0.3, respectively. Thy-1, therefore, provides a potentially useful marker to identify linkages with human disease genes located near 11q22.
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| http://dx.doi.org/10.1016/0198-8859(88)90023-7 | DOI Listing |
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